Publications
Khedmatgozar CR, Holec SAM, and Woerman AL. The role of alpha-synuclein prion strains in Parkinson’s disease and multiple system atrophy. PLoS Pathog. 2024, 20(1):e1011920.
Holec SAM, Lee J, Oehler A, Batia L, Wiggins-Gamble A, Lau J, Ooi FK, Merz GE, Wang M, Mordes DA, Olson SH, and Woerman AL. The E46K mutation modulates alpha-synuclein prion replication in transgenic mice. PLoS Pathog. 2022, 18(12):e1010956.
Holec SAM, Lee J, Oehler A, Ooi FK, Mordes DA, Olson SH, Prusiner SB, and Woerman AL. Multiple system atrophy prions transmit neurological disease to mice expressing wild-type human alpha-synuclein. Acta Neuropathol. 2022. 144(4):677-690.
Holec SAM, Liu SL, and Woerman AL. Consequences of variability in alpha-synuclein fibril structure on strain biology. Acta Neuropathol. 2022. 143(3):311-330.
Ayers JI, Lee J, Monteiro O, Woerman AL, Lazar AA, Condello C, Paras NA, and Prusiner SB. Different alpha-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy. Proc Natl Acad Sci USA. 2022, 119(6):e2113489119.
Woerman AL & Tamgüney G. Body-first Parkinson’s disease and variant Creutzfeldt-Jakob disease - similar or different? Neurobiol Dis. 2022, 164:105625.
Kahriman A, Bouley J, Smith TW, Bosco DA, Woerman AL, Henninger N. Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature. Acta Neuropathol. 2021, 9(1):118.
Woerman AL. Strain diversity in neurodegenerative disease: an argument for a personalized medicine approach to diagnosis and treatment. Acta Neuropathol. 2021, 142(1):1-3.
Lester E, Ooi FK, Bakkar N, Ayers J, Woerman AL, Wheeler, J, Bowser R, Carlson GA, Prusiner SB, and Parker R. Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components. Neuron. 2021, 109(10):1675-1691.
Holec SAM and Woerman AL. Evidence of distinct alpha-synuclein strains underlying disease heterogeneity. Acta Neuropathol. 2021, 142(1):73-86.
Woerman AL, Patel S, Kazmi SA, Oehler A, Lee J, Mordes DA, Olson SH, and Prusiner SB. Kinetics of a-synuclein prions preceding neuropathological inclusions in multiple system atrophy. PLoS Pathog. 2020, 16(2).
Wang X, Williams D, Müller I, Lemieux M, Dukart R, Maia IBL, Wang H, Woerman AL, and Schmitt-Ulms G. Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins. Sci Rep. 2019, 9(1).
Giles K, Woerman AL, Prusiner SB. Prions and TSEs. Disinfection, Sterilization, and Preservation, 6th Edition. Editor: Seymour S. Block. In press.
Aoyagi A, Condello C, Stöhr J, Yue W, Rivera BM, Lee JC, Woerman AL, Halliday G, van Duinen S, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, DeGrado WF, and Prusiner SB. Ab and tau prion-like activities decline with longevity in Alzheimer’s disease human brain. Sci Transl Med. 2019, 11(490).
Woerman AL, Oehler A, Kazmi SA, Lee J, Halliday GM, Middleton LT, Gentleman SM, Mordes DA, Grinberg LT, Olson SH, and Prusiner SB. Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines. Acta Neuropathol. 2019, 137(3):437-454.
Woerman AL, Kazmi SA, Patel S, Aoyagi A, Oehler A, Widjaja K, Mordes DA, Olson SH, and Prusiner SB. Familial Parkinson’s point mutation abolishes multiple system atrophy prion replication. Proc Natl Acad Sci USA. 2018, 115(2):409-414.
Woerman AL, Kazmi SA, Patel S, Freyman Y, Oehler A, Aoyagi A, Mordes DA, Halliday GM, Middleton LT, Gentleman SM, Olson SH, and Prusiner SB. MSA prions exhibit remarkable stability and resistance to inactivation. Acta Neuropathol. 2018, 135(1):49-63.
Woerman AL, Patel S, Kazmi SA, Oehler A, Freyman Y, Espiritu L, Cotter R, Castaneda JA, Olson SH, and Prusiner SB. Kinetics of human mutant tau prion formation in the brains of 2 transgenic mouse lines. JAMA Neurol. 2017, 74(12):1464-1472.
Woerman AL. The importance of developing strain-specific models of neurodegenerative disease. Acta Neuropathol. 2017, 134(5):809-812.
Giles K, Woerman AL, Berry DB, and Prusiner SB. Bioassays and Inactivation of Prions. Cold Spring Harb Perspect Biol. Editor: Stanley B. Prusiner. 2017 Feb 28.
Woerman AL, Watts JC, Aoyagi A, Giles K, Middleton LT, and Prusiner SB. a-Synuclein: Multiple System Atrophy Prions. Cold Spring Harb Perspect Med. Editor: Stanley B. Prusiner. 2017 Feb 17.
Woerman AL & Aoyagi A, Patel S, Kazmi SA, Lobach I, Grinberg LT, McKee AC, Seeley WW, Olson SH, and Prusiner SB. Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells. Proc Natl Acad Sci USA. 2016, 113(50):E8187-E8196.
Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday G, Middleton LT, Gentleman SM, Grinberg LT, and Giles K. Evidence for a-Synuclein Prions Causing Multiple System Atrophy in Humans with Parkinsonism. Proc Natl Acad Sci USA. 2015, 112(38):E5308-E5317.
*Manuscript awarded the Cozzarelli Prize by the National Academy of Sciences (USA).
Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton L, Gentleman SM, Mordes DA, Südhof TC, Giles K, and Prusiner SB. Propagation of prions causing synucleinopathies in cultured cells. Proc Natl Acad Sci USA. 2015, 112(35):E4949-E4958.
Woerman AL and Mendelowitz D. Postnatal Sulfur Dioxide Exposure Reversibly Alters Parasympathetic Regulation of Heart Rate. Hypertension. 2013, 62(2):274-280.
Gorini CG, Jameson H, Woerman AL, Perry DC, Mendelowitz D. Prenatal Nicotine Exposure Enhances Trigeminocardiac Reflex and Brainstem Pathways via Serotonin Receptor Facilitation. Journal of Applied Physiology. 2013, 115(4):415-421.
Woerman AL and Mendelowitz D. Perinatal Sulfur Dioxide Exposure Alters Brainstem Parasympathetic Control of Heart Rate. Cardiovascular Research. 2013, 99(1):16-23.
Boychuk CR, Woerman AL, and Mendelowitz D. Modulation of bulbospinal rostral ventral lateral medulla neurons by hypoxia/hypercapnia but not medullary respiratory activity. Hypertension. 2012, 6(60):1491-1497.